Award Number: W81XWH-09-1-0264 TITLE: Development of a novel NMR-based Rheb GTPase assay and molecular characterization of TSC2 GAP activity. PRINCIPAL INVESTIGATOR:

Award Number: W81XWH-10-1-0753 TITLE: Prospective Molecular Characterization of Burn Wound Colonization: Novel Tools and Analysis PRINCIPAL INVESTIGATOR:

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Tuberous sclerosis complex (TSC) is a genetic disease caused by a mutation in either the tsc1 or tsc2 tumor suppressor gene. Recent studies have demonstrated that TSC2 displays GAP (GTPase-activating protein) activity specifically towards the small G protein Rheb and inhibits its ability to stimulate the mTOR signaling pathway. Rheb and TSC2 comprise a unique pair of GTPase and GAP, because Rhe...

Award Number : W 81 XWH - 07 - 1 - 0448 TITLE : Structural and Mechanistic Analyses of TSC 1 / 2 and Rheb 1 / 2 - Mediated Regulation of the mTORC Pathway

Award Number: W81XWH-07-1-0448 TITLE: Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2Mediated Regulation of the mTORC Pathway PRINCIPAL INVESTIGATOR: PI: David M. Sabatini, M.D./Ph.D. CONTRACTING ORGANIZATION: Whitehead Institute for Biomedical Research Cambridge, MA 02142-1493 REPORT DATE: July 2009 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research and Materiel ...

Award Number: W81XWH-09-1-0679 TITLE: Identification of Inhibitors of PLU-1, a Histone Demethylase that Promotes Breast Cancer Progression PRINCIPAL INVESTIGATOR:

AWARD NUMBER: W81XWH-14-1-0219 TITLE: Novel Molecular Targets for kRAS Downregulation: Promoter G-Quadruplexes PRINCIPAL INVESTIGATOR: CONTRACTING ORGANIZATION: REPORT